Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and risk of colorectal adenoma
نویسندگان
چکیده
Elizabeth M. Poole, Li Hsu, Liren Xiao, Richard J. Kulmacz, Christopher S. Carlson, Peter S. Rabinovitch, Karen W. Makar, John D. Potter, Cornelia M. Ulrich 1 Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 2 Department of Epidemiology, University of Washington, Seattle, Washington, 98195 3 Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, 77030
منابع مشابه
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma.
BACKGROUND Prostaglandins are important inflammatory mediators; prostaglandin E2 (PGE2) is the predominant prostaglandin in colorectal neoplasia and affects colorectal carcinogenesis. Prostaglandins are metabolites of omega-6 and omega-3 polyunsaturated fatty acids; their biosynthesis is the primary target of nonsteroidal anti-inflammatory drugs (NSAID), which reduce colorectal neoplasia risk. ...
متن کاملProstaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
A large body of clinical, genetic, and biochemical evidence indicates that cyclooxygenase-2 (COX-2), a key enzyme for prostanoid biosynthesis, contributes to the promotion of colorectal cancer. COX-2-derived prostaglandin E2 (PGE2) is the most abundant prostaglandin found in several gastrointestinal malignancies. Although PGE2 enhances intestinal adenoma growth in Apcmin mice, the mechanism(s) ...
متن کاملA study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma.
Colorectal cancer (CRC) is the second leading cause of cancer-related death and usually arises from colorectal polyps. Screening and removal of polyps reduce mortality from CRC. Colorectal polyps are known to aggregate in families; however the genetic determinants for risk of polyps are unknown. In addition, it has been shown that nonsteroidal anti-inflammatory drug (NSAID) use decreases the ri...
متن کاملCancer Prevention Research Regulation of Prostaglandin Transporters in Colorectal Neoplasia
Prostaglandin E2 (PGE2) promotes cancer progression by affecting cell proliferation, apoptosis, angiogenesis, and the immune response. It has been reported that PGE2 is transported or passes through the cell membrane via prostaglandin-specific transporters including the prostaglandin transporter (PGT, an influx transporter) and the multidrug resistance-associated protein 4 (an efflux transporte...
متن کاملUrinary prostaglandin E2 metabolite and risk for colorectal adenoma.
COX-2 is upregulated in most colorectal cancers. Most of the COX-2 tumor-inducing effects are believed to be mediated through overproduction of prostaglandin E(2) (PGE(2)), which can be measured using a urinary metabolite of PGE(2), PGE-M. Urinary PGE-M was assessed in a case-control study of colorectal adenoma. Included in the analysis were 224 cases with at least one advanced adenoma, 152 cas...
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تاریخ انتشار 2010